Microsphere-mediated ultrasound represents a new treatment modality for RVO that addresses the underlying cause of the condition. Cerevast’s microspheres have a mean diameter of 1.1 – 3.3 microns and are comprised of a lipid shell and gas core. These microspheres can pass through the retinal vasculature due to their small size. Concomitantly administering ophthalmic ultrasound induces non-linear oscillations, or cavitation of the microspheres in the retinal veins thereby causing a release of energy and subsequent fluid motion in the region of the thrombus. This cavitation-induced energy of fluid motion is believed to be the underlying mechanism leading to clot lysis and reperfusion of retinal tissue. Pre-clinical and clinical studies of microsphere-mediated ophthalmic ultrasound have shown encouraging results as a non-invasive treatment for retinal vein occlusion leading to restored blood flow, reduction in intra-retinal hemorrhage volume and improved visual acuity scores.

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Before treatment, one week after laser occlusion.
Arrow shows clear occlusion of retinal vessel.
After sonolysis treatment, same day.
Arrow shows clear reperfusion in previously occluded retinal vessel.